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Noninvasive fat reduction is claimed by many device manufacturers, but proof of efficacy has been difficult to established. This prospective study was designed to measure the reduction of fat thickness and actual volume reduction in 20 female patients treated with an external radiofrequency (RF) device. This device combines RF heat, suction coupled vacuum, and oscillating electrical pulses that induce adipocyte death over time. Patients underwent pre-and-post-treatment and intercurrent measurements of weight, body mass index, ultrasonic transcutaneous fat thickness, and 2D and 3D Vectra photography with independent calculation of circumferential and volumetric change. Mean transcutaneous ultrasound thickness at reproducible points was 2.78 cm; at 1-month post treatment, the mean fat thickness was 1.71 cm. At 3-month post-treatment, the mean fat thickness reduction was 39.6%. Vectra circumference measurements were taken at 10-mm intervals, with pastureland breathing cycle control. Independent analysis of serial measurements from +60 to – 70mm showed mean abdominal circumference measurement of 2.3 cm. Mean abdominal volume loss was 202.4 and 428.5 cc at 1- and 3-month post-treatment, respectively. Scanning electron microscopy confirmed that permanent cell destruction was caused by irreversible electroporation. Proptosis appears to be the mechanism of action.

Author:
Diane Irvine Duncan, Theresa H. M. Kim, and Robbin Temaat
Technology:
BodyFx.
Published date:
14 February, 2014
Publication:
Journal of Cosmetics and Laser Therapy

Objective: To evaluate the safety and efficacy of a new and novel radiofrequency (RF) device used for focal fat reduction. 

Materials and methods: 24 female and 1 male patients were enrolled in the study. The age range of the patients was 28-62 years old and an average BMI was 26. All patients underwent focal shape correction, without anticipating any weight reduction and 14/24 patients also had posterior or anterior grade 2 or 3 thigh cellulite treated. The patients underwent a 6 treatment protocol where they were treated with a novel RF device on the abdominal and flank regions once a week over a period of 6 weeks. 14 patients also had cellulite on their posterior or anterior thigh treated with the same device and a 6-treatment, once weekly protocol. Therapeutic thermal end points for each treatment were established and achieved as outlined in the paper. The RF device emits both basic RF and ultra-short High Voltage Pulsing (HVP). All patients and zones were treated once per week for 6 weeks.

Results and conclusions: All patients were observed for 3 months following their last treatment to determine the long-term adipose tissue effects and body contour changes. Standard pre and post-operative photography, circumferential measurements were taken. 3 patients who were scheduled for future abdominoplasty surgery had Investigational Review Board compliant lower abdominal subcutaneous biopsies performed at 72 hours and 14 days following their initial RF treatment. The average circumferential reduction was 3.58 cm with range of 1.5 cm-4.4 cm. There were no non-responders observed in the study. Using the modified Nurnberger-Muller 7 stage cellulite grading system, the average cellulite score improved 2 sub-grades. Using the Vectra 3D imaging device and cellulite scoring software, the average starting pit depth was 4.1 mm (range 0.5 mm-7.3 mm). Average Vectra measured improvement in the pit depth or “smoothness score” was 2.9 mm or 60% (range 1.1 mm-6.3 mm). Biopsies revealed histological evidence of the death of proportion fat cells by apoptosis. There were no complications that required medical management. We conclude that the TiteFX appears to offer a safe and effective option for the non-invasive management of both focal fat excess and cellulite. The basic RF and High Voltage pulses appear to result in a long term, proportional death of fat tissue, presumably through adipocyte apoptosis.

Author:
Dr. S. Mulholland
Technology:
BodyFx.
Published date:
14 February, 2014
Publication:
Clinical & Experimental Dermatology Research

With many products targeted to treat acne over the last few years, many dermatologists are finding high success rates using radiofrequency (RF) microneedling devices, specifically Fractora.
This new technology has shown a great improvement not only on patients’ acne, but additionally acne scarring, axillary hyperhidrosis, neck tightening, stretch marks and treatment of the vertical lines women can develop on their chest area. A unique feature to Fractora is that the technology allows users of the 24-pin needles to choose between regular tips and tips with silicone coating to protect the epidermis and the top layers of the dermis from heat injury. With Fractora, an additional benefit is all skin types can be treated, up to the darkest type VI skin without risk of pigmentation changes. With such technology, acne scarring is improved up to 75-80% in patients with downtime as low as 24 hours over the course of one treatment.

Author:
Judith Hellman
Technology:
Fractora.
Published date:
05 February, 2014
Publication:
Dermatology Times

Abstract:
Background Aging can lead to changes in facial expressions, transforming the positive youth expression of happiness to negative expressions as sadness, tiredness, and disgust. Local skin distension is another consequence of aging, which can be difficult to treat with rejuvenation procedures. The “face expressive lifting” (FEL) is an original concept in facial rejuvenation surgery. On the one hand, FEL integrates established convergent surgical techniques aiming to correct the agerelated negative facial expressions. On the other hand, FEL incorporates novel bipolar RF technology aiming to correct local skin distension. Methods One hundred twenty-six patients underwent FEL procedure. Facial expression and local skin distension were assessed with 2 years follow-up. Results There was a correction of negative facial expression for 96 patients (76 %) and a tightening of local skin distension in 100 % of cases. Conclusions FEL is an effective procedure taking into account and able to correct both age-related negative changes in facial expression and local skin distension using radiofrequency. Level of Evidence: Level IV, therapeutic study.

Introduction:
The recent years have seen a better understanding of the physiopathogenesis and manifestations of facial aging such as sagging due to gravity, fat loss and redistribution, and loss of bone volume [1–5]. However, aging can also lead to changes in facial expressions, transforming the positive youth expressions (happiness) to negative expressions (sadness, tiredness, and disgust) overtime [6, 7]. These projected “negative emotions” can impact other’s views of us and social interaction. This might explain that a high number of patients ask not only for cosmetic improvement but also for improvement of unattractive facial expression. Almost no studies have clearly analyzed and shown how to correct the age-related changes on facial expression. The FEL concept was developed upon the convergence of effects of rejuvenation surgical procedures on different levels of the face with priority given to the re-establishment of “vitality” in both the eyes and the smile, which are the key of emotions expressions. The present study aimed to address the question of wether the FEL could correct negative facial expressions of the aging face. Secondly, the skin of the face loses its tonicity over time. Although a lift can eliminate remaining folds after musculocutaneous tightening, simple redraping is not always sufficient in cases of local distension. The application of bipolar radiofrequency (RF), using FaceTite™ (Invasix Ltd., Yokneam, Israel) makes it possible to obtain stable quantitative and qualitative effects on the skin over time through the regeneration of the deep dermis and superficial subdermal septo-fascial fat [12]. The second question addressed was whether we could correct local skin distension on zones of weak facial skin (malar crescent, labio-jugal, and submental) using radiofrequency.

Author:
M. Divaris, G. Blugerman, and M. Paul
Technology:
BodyTite, FaceTite.
Published date:
06 December, 2013
Publication:
European Journal of Plastic Surgery

Background:
Contouring of the arms that does not involve skin excision remains a difficult challenge due to the dependent nature and quality of the skin. Although brachioplasty remains effective, it requires lengthy incision. Radiofrequency-assisted liposuction (RFAL) may improve skin retraction with a satisfactory aesthetic result without skin resection and the resultant scar. The purpose of this study is to present our experience of RFAL arm contouring under local anesthesia, detailing safety guidelines, the marking technique, operative technique, complications, third party surgeon appraisal, and patient satisfaction survey

Methods:
Forty patients underwent RFAL under local tumescent anesthesia for aesthetic arm contouring. Postoperative patient satisfaction surveys were conducted and independent third-party surgeons were surveyed to assess improvements in contour and skin quality with preoperative and postoperative photographs

Conclusion:
In appropriately selected patients, RFAL arm contouring under local anesthesia represents and alternative procedure with acceptably low morbidity and high patient satisfaction. To achieve consistent results while minimizing complication, consideration to anatomic details, infiltration of the local anesthetic, and application of the radiofrequency energy must be given.

Author:
S. Theodorou, MD & C. Chia, MD
Technology:
BodyTite, FaceTite.
Published date:
10 September, 2013
Publication:
PRS

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